2XK8
Structure of Nek2 bound to aminopyrazine compound 15
Summary for 2XK8
Entry DOI | 10.2210/pdb2xk8/pdb |
Related | 2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP |
Descriptor | SERINE/THREONINE-PROTEIN KINASE NEK2, 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methoxybenzoic acid, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | transferase, centrosome, mitosis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus. Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm: P51955 |
Total number of polymer chains | 1 |
Total formula weight | 33215.70 |
Authors | Mas-Droux, C.,Bayliss, R. (deposition date: 2010-07-07, release date: 2010-10-27, Last modification date: 2023-12-20) |
Primary citation | Whelligan, D.K.,Solanki, S.,Taylor, D.,Thomson, D.W.,Cheung, K.M.,Boxall, K.,Mas-Droux, C.,Barillari, C.,Burns, S.,Grummitt, C.G.,Collins, I.,Van Montfort, R.L.,Aherne, G.W.,Bayliss, R.,Hoelder, S. Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization. J.Med.Chem., 53:7682-, 2010 Cited by PubMed: 20936789DOI: 10.1021/JM1008727 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.001 Å) |
Structure validation
Download full validation report