2XJ1

Protein kinase Pim-1 in complex with small molecule inibitor

Summary for 2XJ1

Entry DOI	10.2210/pdb2xj1/pdb
Related	1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XIZ 2XJ0 2XJ2
Descriptor	PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, (2E)-3-(3-{6-[(TRANS-4-AMINOCYCLOHEXYL)AMINO]PYRAZIN-2-YL}PHENYL)PROP-2-ENOIC ACID (3 entities in total)
Functional Keywords	phosphorylation, transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34727.34
Authors	Schulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C. (deposition date: 2010-07-01, release date: 2011-02-23, Last modification date: 2011-07-13)
Primary citation	Schulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C. Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67:156-, 2011 Cited by PubMed: 21358046 DOI: 10.1107/S0907444910054144 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation