2XIZ
Protein kinase Pim-1 in complex with fragment-3 from crystallographic fragment screen
Summary for 2XIZ
Entry DOI | 10.2210/pdb2xiz/pdb |
Related | 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XJ0 2XJ1 2XJ2 |
Descriptor | PROTO-ONCOGENE SERINE/THREONINE PROTEIN KINASE PIM-1, (E)-PYRIDIN-4-YL-ACRYLIC ACID (3 entities in total) |
Functional Keywords | phosphorylation, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 34538.08 |
Authors | Schulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C. (deposition date: 2010-07-01, release date: 2011-02-23, Last modification date: 2024-10-09) |
Primary citation | Schulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C. Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67:156-, 2011 Cited by PubMed: 21358046DOI: 10.1107/S0907444910054144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
Download full validation report