2XE0

Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus

Summary for 2XE0

• Entry DOI: 10.2210/pdb2xe0/pdb
• Descriptor: I-CREI V2V3 VARIANT, 24MER DNA, ACETATE ION, ... (8 entities in total)
• Functional Keywords: dna binding protein-dna complex, homing endonucleases, double-strand break, homologous recombination, human rag1 gene, severe combined immunodeficiency (scid), dna binding protein, dna binding protein/dna
• Biological source: CHLAMYDOMONAS REINHARDTII; More
• Total number of polymer chains: 4
• Total formula weight: 49192.67

Authors

Munoz, I.G.,Prieto, J.,Subramanian, S.,Coloma, J.,Redondo, P.,Villate, M.,Merino, N.,Marenchino, M.,D'Abramo, M.,Gervasio, F.L.,Grizot, S.,Daboussi, F.,Smith, J.,Chion-Sotine, I.,Paques, F.,Duchateau, P.,Alibes, A.,Stricher, F.,Serrano, L.,Blanco, F.J.,Montoya, G. (deposition date: 2010-05-10, release date: 2010-09-29, Last modification date: 2023-12-20)

• Primary citation: Munoz, I.G.,Prieto, J.,Subramanian, S.,Coloma, J.,Redondo, P.,Villate, M.,Merino, N.,Marenchino, M.,D'Abramo, M.,Gervasio, F.L.,Grizot, S.,Daboussi, F.,Smith, J.,Chion-Sotine, I.,Paques, F.,Duchateau, P.,Alibes, A.,Stricher, F.,Serrano, L.,Blanco, F.J.,Montoya, G.; Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus; Nucleic Acids Res., 39:729-743, 2011; PubMed: 20846960; DOI: 10.1093/NAR/GKQ801

Experimental method

X-RAY DIFFRACTION (2.31 Å)