2XE0
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Summary for 2XE0
Entry DOI | 10.2210/pdb2xe0/pdb |
Descriptor | I-CREI V2V3 VARIANT, 24MER DNA, ACETATE ION, ... (8 entities in total) |
Functional Keywords | dna binding protein-dna complex, homing endonucleases, double-strand break, homologous recombination, human rag1 gene, severe combined immunodeficiency (scid), dna binding protein, dna binding protein/dna |
Biological source | CHLAMYDOMONAS REINHARDTII More |
Total number of polymer chains | 4 |
Total formula weight | 49192.67 |
Authors | Munoz, I.G.,Prieto, J.,Subramanian, S.,Coloma, J.,Redondo, P.,Villate, M.,Merino, N.,Marenchino, M.,D'Abramo, M.,Gervasio, F.L.,Grizot, S.,Daboussi, F.,Smith, J.,Chion-Sotine, I.,Paques, F.,Duchateau, P.,Alibes, A.,Stricher, F.,Serrano, L.,Blanco, F.J.,Montoya, G. (deposition date: 2010-05-10, release date: 2010-09-29, Last modification date: 2023-12-20) |
Primary citation | Munoz, I.G.,Prieto, J.,Subramanian, S.,Coloma, J.,Redondo, P.,Villate, M.,Merino, N.,Marenchino, M.,D'Abramo, M.,Gervasio, F.L.,Grizot, S.,Daboussi, F.,Smith, J.,Chion-Sotine, I.,Paques, F.,Duchateau, P.,Alibes, A.,Stricher, F.,Serrano, L.,Blanco, F.J.,Montoya, G. Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus Nucleic Acids Res., 39:729-743, 2011 Cited by PubMed: 20846960DOI: 10.1093/NAR/GKQ801 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
Download full validation report