2XBN

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

Summary for 2XBN

Entry DOI	10.2210/pdb2xbn/pdb
Related	2JG2 2JGT 2W8J 2W8T 2W8U 2W8V 2W8W
Descriptor	SERINE PALMITOYLTRANSFERASE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	transferase, pyridoxal phosphate
Biological source	SPHINGOMONAS PAUCIMOBILIS
Total number of polymer chains	1
Total formula weight	46303.03
Authors	Lowther, J.,Yard, B.A.,Johnson, K.A.,Carter, L.G.,Bhat, V.T.,Raman, M.C.C.,Clarke, D.J.,Ramakers, B.,McMahon, S.A.,Naismith, J.H.,Campopiano, D.J. (deposition date: 2010-04-13, release date: 2010-05-19, Last modification date: 2011-07-13)
Primary citation	Lowther, J.,Yard, B.A.,Johnson, K.A.,Carter, L.G.,Bhat, V.T.,Raman, M.C.C.,Clarke, D.J.,Ramakers, B.,Mcmahon, S.A.,Naismith, J.H.,Campopiano, D.J. Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase by Cycloserine: Evidence for a Novel Decarboxylative Mechanism of Inactivation. Mol.Biosystems, 6:1682-, 2010 Cited by PubMed: 20445930 DOI: 10.1039/C003743E PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation