2XBN

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SERINE PALMITOYLTRANSFERASE	polymer	427	46030.6	1	UniProt (Q93UV0) Pfam (PF00155) In PDB	SPHINGOMONAS PAUCIMOBILIS	SPT, SPT1
2	A	4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE	non-polymer		248.2	1	Chemie (PMP)
3	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4		water	water		18.0	298	Chemie (HOH)

Sequence modifications

A: 2 - 420 (UniProt: Q93UV0)

PDB	External Database	Details
Leu 421	-	expression tag
Glu 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	46030.6
Non-Polymers*	Number of molecules	2
	Total formula weight	272.5
All*	Total formula weight	46303.0

*Water molecules are not included.