2X9V

High resolution structure of TbPTR1 with trimetrexate

2X9V の概要

• エントリーDOI: 10.2210/pdb2x9v/pdb
• 関連するPDBエントリー: 2C7V 2VZ0 2WD7 2WD8 2X9N
• 分子名称: PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, short chain dehydrogenase
• 由来する生物種: TRYPANOSOMA BRUCEI BRUCEI
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127488.75

構造登録者

Dawson, A.,Tulloch, L.B.,Barrack, K.L.,Hunter, W.N. (登録日: 2010-03-24, 公開日: 2010-06-23, 最終更新日: 2024-05-08)

主引用文献

Dawson, A.,Tulloch, L.B.,Barrack, K.L.,Hunter, W.N.
High-Resolution Structures of Trypanosoma Brucei Pteridine Reductase Ligand Complexes Inform on the Placement of New Molecular Entities in the Active Site of a Potential Drug Target
Acta Crystallogr.,Sect.D, 66:1334-, 2010

PubMed Abstract: Pteridine reductase (PTR1) is a potential target for drug development against parasitic Trypanosoma and Leishmania species. These protozoa cause serious diseases for which current therapies are inadequate. High-resolution structures have been determined, using data between 1.6 and 1.1 Å resolution, of T. brucei PTR1 in complex with pemetrexed, trimetrexate, cyromazine and a 2,4-diaminopyrimidine derivative. The structures provide insight into the interactions formed by new molecular entities in the enzyme active site with ligands that represent lead compounds for structure-based inhibitor development and to support early-stage drug discovery.

PubMed: 21123874
DOI: 10.1107/S0907444910040886

実験手法

X-RAY DIFFRACTION (1.3 Å)