2X9V

High resolution structure of TbPTR1 with trimetrexate

Summary for 2X9V

Entry DOI	10.2210/pdb2x9v/pdb
Related	2C7V 2VZ0 2WD7 2WD8 2X9N
Descriptor	PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ... (5 entities in total)
Functional Keywords	oxidoreductase, short chain dehydrogenase
Biological source	TRYPANOSOMA BRUCEI BRUCEI
Total number of polymer chains	4
Total formula weight	127488.75
Authors	Dawson, A.,Tulloch, L.B.,Barrack, K.L.,Hunter, W.N. (deposition date: 2010-03-24, release date: 2010-06-23, Last modification date: 2024-05-08)
Primary citation	Dawson, A.,Tulloch, L.B.,Barrack, K.L.,Hunter, W.N. High-Resolution Structures of Trypanosoma Brucei Pteridine Reductase Ligand Complexes Inform on the Placement of New Molecular Entities in the Active Site of a Potential Drug Target Acta Crystallogr.,Sect.D, 66:1334-, 2010 Cited by PubMed: 21123874 DOI: 10.1107/S0907444910040886 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation