2X9G
High resolution structure of TbPTR1 in complex with Pemetrexed
Summary for 2X9G
Entry DOI | 10.2210/pdb2x9g/pdb |
Related | 2C7V 2VZ0 2WD7 2WD8 2X9N 2X9V |
Descriptor | PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, ... (5 entities in total) |
Functional Keywords | short chain dehydrogenase, oxidoreductase |
Biological source | TRYPANOSOMA BRUCEI BRUCEI |
Total number of polymer chains | 4 |
Total formula weight | 127421.47 |
Authors | Dawson, A.,Barrack, K.L.,Tulloch, L.B.,Hunter, W.N. (deposition date: 2010-03-18, release date: 2010-06-16, Last modification date: 2024-05-08) |
Primary citation | Dawson, A.,Tulloch, L.B.,Barrack, K.L.,Hunter, W.N. High-Resolution Structures of Trypanosoma Brucei Pteridine Reductase Ligand Complexes Inform on the Placement of New Molecular Entities in the Active Site of a Potential Drug Target Acta Crystallogr.,Sect.D, 66:1334-, 2010 Cited by PubMed: 21123874DOI: 10.1107/S0907444910040886 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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