2X6J

THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93

Summary for 2X6J

Entry DOI	10.2210/pdb2x6j/pdb
Related	2X6F 2X6H 2X6I 2X6K
Descriptor	PHOSPHOTIDYLINOSITOL 3 KINASE 59F, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE (2 entities in total)
Functional Keywords	transferase
Biological source	DROSOPHILA MELANOGASTER (FRUIT FLY)
Total number of polymer chains	2
Total formula weight	158310.69
Authors	Miller, S.,Tavshanjian, B.,Oleksy, A.,Perisic, O.,Houseman, B.T.,Shokat, K.M.,Williams, R.L. (deposition date: 2010-02-17, release date: 2010-04-07, Last modification date: 2023-12-20)
Primary citation	Miller, S.,Tavshanjian, B.,Oleksy, A.,Perisic, O.,Houseman, B.T.,Shokat, K.M.,Williams, R.L. Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34. Science, 327:1638-, 2010 Cited by PubMed: 20339072 DOI: 10.1126/SCIENCE.1184429 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation