2X38

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.

「2WXE」から置き換えられました

2X38 の概要

• エントリーDOI: 10.2210/pdb2x38/pdb
• 分子名称: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE (3 entities in total)
• 機能のキーワード: phosphoinositide 3-kinase, isoform-specific inhibitors, cancer, transferase
• 由来する生物種: MUS MUSCULUS (MOUSE)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108221.10

構造登録者

Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L. (登録日: 2010-01-22, 公開日: 2010-02-02, 最終更新日: 2023-12-20)

• 主引用文献: Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L.; The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors; Nat.Chem.Biol., 6:117-, 2010; PubMed: 20081827; DOI: 10.1038/NCHEMBIO.293

実験手法

X-RAY DIFFRACTION (2.2 Å)