2X0B

Crystal structure of human angiotensinogen complexed with renin

Summary for 2X0B

• Entry DOI: 10.2210/pdb2x0b/pdb
• Related: 2WXW 2WXX 2WXY 2WXZ 2WY0 2WY1
• Descriptor: RENIN, ANGIOTENSINOGEN (2 entities in total)
• Functional Keywords: hydrolase-hormone complex, hydrolase hormone complex, vasoconstrictor, glycoprotein, hypertension, serpins, zymogen, hydrolase, vasoactive, hydrolase/hormone
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P00797 P01019
• Total number of polymer chains: 8
• Total formula weight: 368687.46

Authors

Zhou, A.,Wei, Z.,Yan, Y.,Carrell, R.W.,Read, R.J. (deposition date: 2009-12-08, release date: 2010-10-20, Last modification date: 2023-12-20)

• Primary citation: Zhou, A.,Carrell, R.W.,Murphy, M.P.,Wei, Z.,Yan, Y.,Stanley, P.L.,Stein, P.E.,Pipkin, F.B.,Read, R.J.; A Redox Switch in Angiotensinogen Modulates Angiotensin Release.; Nature, 468:108-, 2010; PubMed: 20927107; DOI: 10.1038/NATURE09505

Experimental method

X-RAY DIFFRACTION (4.33 Å)