Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2X0B

Crystal structure of human angiotensinogen complexed with renin

Functional Information from GO Data
ChainGOidnamespacecontents
A0001822biological_processkidney development
A0001823biological_processmesonephros development
A0002003biological_processangiotensin maturation
A0002016biological_processregulation of blood volume by renin-angiotensin
A0002018biological_processrenin-angiotensin regulation of aldosterone production
A0004175molecular_functionendopeptidase activity
A0004190molecular_functionaspartic-type endopeptidase activity
A0005102molecular_functionsignaling receptor binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008217biological_processregulation of blood pressure
A0008233molecular_functionpeptidase activity
A0008584biological_processmale gonad development
A0009410biological_processresponse to xenobiotic stimulus
A0009755biological_processhormone-mediated signaling pathway
A0010467biological_processgene expression
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0032496biological_processresponse to lipopolysaccharide
A0035902biological_processresponse to immobilization stress
A0042756biological_processdrinking behavior
A0043408biological_processregulation of MAPK cascade
A0045177cellular_componentapical part of cell
A0048469biological_processcell maturation
A0050435biological_processamyloid-beta metabolic process
A0051591biological_processresponse to cAMP
A0070305biological_processresponse to cGMP
A0071466biological_processcellular response to xenobiotic stimulus
A0072051biological_processjuxtaglomerular apparatus development
B0001558biological_processregulation of cell growth
B0001819biological_processpositive regulation of cytokine production
B0001822biological_processkidney development
B0001974biological_processblood vessel remodeling
B0002016biological_processregulation of blood volume by renin-angiotensin
B0002018biological_processrenin-angiotensin regulation of aldosterone production
B0002019biological_processregulation of renal output by angiotensin
B0002034biological_processmaintenance of blood vessel diameter homeostasis by renin-angiotensin
B0003014biological_processrenal system process
B0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005179molecular_functionhormone activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0007186biological_processG protein-coupled receptor signaling pathway
B0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007267biological_processcell-cell signaling
B0008083molecular_functiongrowth factor activity
B0008217biological_processregulation of blood pressure
B0010595biological_processpositive regulation of endothelial cell migration
B0010613biological_processpositive regulation of cardiac muscle hypertrophy
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010744biological_processpositive regulation of macrophage derived foam cell differentiation
B0014873biological_processresponse to muscle activity involved in regulation of muscle adaptation
B0019229biological_processregulation of vasoconstriction
B0031012cellular_componentextracellular matrix
B0031702molecular_functiontype 1 angiotensin receptor binding
B0031703molecular_functiontype 2 angiotensin receptor binding
B0034374biological_processlow-density lipoprotein particle remodeling
B0035813biological_processregulation of renal sodium excretion
B0038060biological_processnitric oxide-cGMP-mediated signaling
B0038166biological_processangiotensin-activated signaling pathway
B0042127biological_processregulation of cell population proliferation
B0042310biological_processvasoconstriction
B0042981biological_processregulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043407biological_processnegative regulation of MAP kinase activity
B0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
B0045893biological_processpositive regulation of DNA-templated transcription
B0048146biological_processpositive regulation of fibroblast proliferation
B0050729biological_processpositive regulation of inflammatory response
B0051387biological_processnegative regulation of neurotrophin TRK receptor signaling pathway
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0070062cellular_componentextracellular exosome
B0070294biological_processrenal sodium ion absorption
B0072562cellular_componentblood microparticle
B0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
B0090205biological_processpositive regulation of cholesterol metabolic process
B0097746biological_processblood vessel diameter maintenance
B0110063biological_processpositive regulation of angiotensin-activated signaling pathway
B1901201biological_processregulation of extracellular matrix assembly
B1901203biological_processpositive regulation of extracellular matrix assembly
B1902895biological_processpositive regulation of miRNA transcription
B1903598biological_processpositive regulation of gap junction assembly
B1903779biological_processregulation of cardiac conduction
B1990776biological_processresponse to angiotensin
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
B2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
C0001822biological_processkidney development
C0001823biological_processmesonephros development
C0002003biological_processangiotensin maturation
C0002016biological_processregulation of blood volume by renin-angiotensin
C0002018biological_processrenin-angiotensin regulation of aldosterone production
C0004175molecular_functionendopeptidase activity
C0004190molecular_functionaspartic-type endopeptidase activity
C0005102molecular_functionsignaling receptor binding
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0008217biological_processregulation of blood pressure
C0008233molecular_functionpeptidase activity
C0008584biological_processmale gonad development
C0009410biological_processresponse to xenobiotic stimulus
C0009755biological_processhormone-mediated signaling pathway
C0010467biological_processgene expression
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0032496biological_processresponse to lipopolysaccharide
C0035902biological_processresponse to immobilization stress
C0042756biological_processdrinking behavior
C0043408biological_processregulation of MAPK cascade
C0045177cellular_componentapical part of cell
C0048469biological_processcell maturation
C0050435biological_processamyloid-beta metabolic process
C0051591biological_processresponse to cAMP
C0070305biological_processresponse to cGMP
C0071466biological_processcellular response to xenobiotic stimulus
C0072051biological_processjuxtaglomerular apparatus development
D0001558biological_processregulation of cell growth
D0001819biological_processpositive regulation of cytokine production
D0001822biological_processkidney development
D0001974biological_processblood vessel remodeling
D0002016biological_processregulation of blood volume by renin-angiotensin
D0002018biological_processrenin-angiotensin regulation of aldosterone production
D0002019biological_processregulation of renal output by angiotensin
D0002034biological_processmaintenance of blood vessel diameter homeostasis by renin-angiotensin
D0003014biological_processrenal system process
D0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
D0004867molecular_functionserine-type endopeptidase inhibitor activity
D0005179molecular_functionhormone activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0007186biological_processG protein-coupled receptor signaling pathway
D0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007267biological_processcell-cell signaling
D0008083molecular_functiongrowth factor activity
D0008217biological_processregulation of blood pressure
D0010595biological_processpositive regulation of endothelial cell migration
D0010613biological_processpositive regulation of cardiac muscle hypertrophy
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010744biological_processpositive regulation of macrophage derived foam cell differentiation
D0014873biological_processresponse to muscle activity involved in regulation of muscle adaptation
D0019229biological_processregulation of vasoconstriction
D0031012cellular_componentextracellular matrix
D0031702molecular_functiontype 1 angiotensin receptor binding
D0031703molecular_functiontype 2 angiotensin receptor binding
D0034374biological_processlow-density lipoprotein particle remodeling
D0035813biological_processregulation of renal sodium excretion
D0038060biological_processnitric oxide-cGMP-mediated signaling
D0038166biological_processangiotensin-activated signaling pathway
D0042127biological_processregulation of cell population proliferation
D0042310biological_processvasoconstriction
D0042981biological_processregulation of apoptotic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043407biological_processnegative regulation of MAP kinase activity
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045893biological_processpositive regulation of DNA-templated transcription
D0048146biological_processpositive regulation of fibroblast proliferation
D0050729biological_processpositive regulation of inflammatory response
D0051387biological_processnegative regulation of neurotrophin TRK receptor signaling pathway
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0070062cellular_componentextracellular exosome
D0070294biological_processrenal sodium ion absorption
D0072562cellular_componentblood microparticle
D0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
D0090205biological_processpositive regulation of cholesterol metabolic process
D0097746biological_processblood vessel diameter maintenance
D0110063biological_processpositive regulation of angiotensin-activated signaling pathway
D1901201biological_processregulation of extracellular matrix assembly
D1901203biological_processpositive regulation of extracellular matrix assembly
D1902895biological_processpositive regulation of miRNA transcription
D1903598biological_processpositive regulation of gap junction assembly
D1903779biological_processregulation of cardiac conduction
D1990776biological_processresponse to angiotensin
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
D2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
E0001822biological_processkidney development
E0001823biological_processmesonephros development
E0002003biological_processangiotensin maturation
E0002016biological_processregulation of blood volume by renin-angiotensin
E0002018biological_processrenin-angiotensin regulation of aldosterone production
E0004175molecular_functionendopeptidase activity
E0004190molecular_functionaspartic-type endopeptidase activity
E0005102molecular_functionsignaling receptor binding
E0005159molecular_functioninsulin-like growth factor receptor binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005886cellular_componentplasma membrane
E0006508biological_processproteolysis
E0008217biological_processregulation of blood pressure
E0008233molecular_functionpeptidase activity
E0008584biological_processmale gonad development
E0009410biological_processresponse to xenobiotic stimulus
E0009755biological_processhormone-mediated signaling pathway
E0010467biological_processgene expression
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0032496biological_processresponse to lipopolysaccharide
E0035902biological_processresponse to immobilization stress
E0042756biological_processdrinking behavior
E0043408biological_processregulation of MAPK cascade
E0045177cellular_componentapical part of cell
E0048469biological_processcell maturation
E0050435biological_processamyloid-beta metabolic process
E0051591biological_processresponse to cAMP
E0070305biological_processresponse to cGMP
E0071466biological_processcellular response to xenobiotic stimulus
E0072051biological_processjuxtaglomerular apparatus development
F0001558biological_processregulation of cell growth
F0001819biological_processpositive regulation of cytokine production
F0001822biological_processkidney development
F0001974biological_processblood vessel remodeling
F0002016biological_processregulation of blood volume by renin-angiotensin
F0002018biological_processrenin-angiotensin regulation of aldosterone production
F0002019biological_processregulation of renal output by angiotensin
F0002034biological_processmaintenance of blood vessel diameter homeostasis by renin-angiotensin
F0003014biological_processrenal system process
F0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
F0004867molecular_functionserine-type endopeptidase inhibitor activity
F0005179molecular_functionhormone activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0007186biological_processG protein-coupled receptor signaling pathway
F0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
F0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
F0007267biological_processcell-cell signaling
F0008083molecular_functiongrowth factor activity
F0008217biological_processregulation of blood pressure
F0010595biological_processpositive regulation of endothelial cell migration
F0010613biological_processpositive regulation of cardiac muscle hypertrophy
F0010718biological_processpositive regulation of epithelial to mesenchymal transition
F0010744biological_processpositive regulation of macrophage derived foam cell differentiation
F0014873biological_processresponse to muscle activity involved in regulation of muscle adaptation
F0019229biological_processregulation of vasoconstriction
F0031012cellular_componentextracellular matrix
F0031702molecular_functiontype 1 angiotensin receptor binding
F0031703molecular_functiontype 2 angiotensin receptor binding
F0034374biological_processlow-density lipoprotein particle remodeling
F0035813biological_processregulation of renal sodium excretion
F0038060biological_processnitric oxide-cGMP-mediated signaling
F0038166biological_processangiotensin-activated signaling pathway
F0042127biological_processregulation of cell population proliferation
F0042310biological_processvasoconstriction
F0042981biological_processregulation of apoptotic process
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0043407biological_processnegative regulation of MAP kinase activity
F0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
F0045893biological_processpositive regulation of DNA-templated transcription
F0048146biological_processpositive regulation of fibroblast proliferation
F0050729biological_processpositive regulation of inflammatory response
F0051387biological_processnegative regulation of neurotrophin TRK receptor signaling pathway
F0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0070062cellular_componentextracellular exosome
F0070294biological_processrenal sodium ion absorption
F0072562cellular_componentblood microparticle
F0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
F0090205biological_processpositive regulation of cholesterol metabolic process
F0097746biological_processblood vessel diameter maintenance
F0110063biological_processpositive regulation of angiotensin-activated signaling pathway
F1901201biological_processregulation of extracellular matrix assembly
F1901203biological_processpositive regulation of extracellular matrix assembly
F1902895biological_processpositive regulation of miRNA transcription
F1903598biological_processpositive regulation of gap junction assembly
F1903779biological_processregulation of cardiac conduction
F1990776biological_processresponse to angiotensin
F2000379biological_processpositive regulation of reactive oxygen species metabolic process
F2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
G0001822biological_processkidney development
G0001823biological_processmesonephros development
G0002003biological_processangiotensin maturation
G0002016biological_processregulation of blood volume by renin-angiotensin
G0002018biological_processrenin-angiotensin regulation of aldosterone production
G0004175molecular_functionendopeptidase activity
G0004190molecular_functionaspartic-type endopeptidase activity
G0005102molecular_functionsignaling receptor binding
G0005159molecular_functioninsulin-like growth factor receptor binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005886cellular_componentplasma membrane
G0006508biological_processproteolysis
G0008217biological_processregulation of blood pressure
G0008233molecular_functionpeptidase activity
G0008584biological_processmale gonad development
G0009410biological_processresponse to xenobiotic stimulus
G0009755biological_processhormone-mediated signaling pathway
G0010467biological_processgene expression
G0016020cellular_componentmembrane
G0016787molecular_functionhydrolase activity
G0032496biological_processresponse to lipopolysaccharide
G0035902biological_processresponse to immobilization stress
G0042756biological_processdrinking behavior
G0043408biological_processregulation of MAPK cascade
G0045177cellular_componentapical part of cell
G0048469biological_processcell maturation
G0050435biological_processamyloid-beta metabolic process
G0051591biological_processresponse to cAMP
G0070305biological_processresponse to cGMP
G0071466biological_processcellular response to xenobiotic stimulus
G0072051biological_processjuxtaglomerular apparatus development
H0001558biological_processregulation of cell growth
H0001819biological_processpositive regulation of cytokine production
H0001822biological_processkidney development
H0001974biological_processblood vessel remodeling
H0002016biological_processregulation of blood volume by renin-angiotensin
H0002018biological_processrenin-angiotensin regulation of aldosterone production
H0002019biological_processregulation of renal output by angiotensin
H0002034biological_processmaintenance of blood vessel diameter homeostasis by renin-angiotensin
H0003014biological_processrenal system process
H0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
H0004867molecular_functionserine-type endopeptidase inhibitor activity
H0005179molecular_functionhormone activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0007186biological_processG protein-coupled receptor signaling pathway
H0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
H0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
H0007267biological_processcell-cell signaling
H0008083molecular_functiongrowth factor activity
H0008217biological_processregulation of blood pressure
H0010595biological_processpositive regulation of endothelial cell migration
H0010613biological_processpositive regulation of cardiac muscle hypertrophy
H0010718biological_processpositive regulation of epithelial to mesenchymal transition
H0010744biological_processpositive regulation of macrophage derived foam cell differentiation
H0014873biological_processresponse to muscle activity involved in regulation of muscle adaptation
H0019229biological_processregulation of vasoconstriction
H0031012cellular_componentextracellular matrix
H0031702molecular_functiontype 1 angiotensin receptor binding
H0031703molecular_functiontype 2 angiotensin receptor binding
H0034374biological_processlow-density lipoprotein particle remodeling
H0035813biological_processregulation of renal sodium excretion
H0038060biological_processnitric oxide-cGMP-mediated signaling
H0038166biological_processangiotensin-activated signaling pathway
H0042127biological_processregulation of cell population proliferation
H0042310biological_processvasoconstriction
H0042981biological_processregulation of apoptotic process
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0043407biological_processnegative regulation of MAP kinase activity
H0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
H0045893biological_processpositive regulation of DNA-templated transcription
H0048146biological_processpositive regulation of fibroblast proliferation
H0050729biological_processpositive regulation of inflammatory response
H0051387biological_processnegative regulation of neurotrophin TRK receptor signaling pathway
H0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
H0070062cellular_componentextracellular exosome
H0070294biological_processrenal sodium ion absorption
H0072562cellular_componentblood microparticle
H0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
H0090205biological_processpositive regulation of cholesterol metabolic process
H0097746biological_processblood vessel diameter maintenance
H0110063biological_processpositive regulation of angiotensin-activated signaling pathway
H1901201biological_processregulation of extracellular matrix assembly
H1901203biological_processpositive regulation of extracellular matrix assembly
H1902895biological_processpositive regulation of miRNA transcription
H1903598biological_processpositive regulation of gap junction assembly
H1903779biological_processregulation of cardiac conduction
H1990776biological_processresponse to angiotensin
H2000379biological_processpositive regulation of reactive oxygen species metabolic process
H2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
ChainResidueDetails
AVAL30-VAL41
AALA216-GLY227

site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. VTLNRPFLFaV
ChainResidueDetails
BVAL421-VAL431

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3934016
ChainResidueDetails
BILE5
DILE5
FILE5
HILE5
EASP33
EASP219
GASP33
GASP219

site_idSWS_FT_FI2
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3934016
ChainResidueDetails
BILE128
HILE128
HALA262
HPHE286
BALA262
BPHE286
DILE128
DALA262
DPHE286
FILE128
FALA262
FPHE286

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon