2X0B

Crystal structure of human angiotensinogen complexed with renin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001822	biological_process	kidney development
A	0001823	biological_process	mesonephros development
A	0002003	biological_process	angiotensin maturation
A	0004175	molecular_function	endopeptidase activity
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0005102	molecular_function	signaling receptor binding
A	0005159	molecular_function	insulin-like growth factor receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008217	biological_process	regulation of blood pressure
A	0008233	molecular_function	peptidase activity
A	0008584	biological_process	male gonad development
A	0009410	biological_process	response to xenobiotic stimulus
A	0010467	biological_process	gene expression
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0032496	biological_process	response to lipopolysaccharide
A	0035902	biological_process	response to immobilization stress
A	0043408	biological_process	regulation of MAPK cascade
A	0045177	cellular_component	apical part of cell
A	0051591	biological_process	response to cAMP
A	0070305	biological_process	response to cGMP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0072051	biological_process	juxtaglomerular apparatus development
B	0001558	biological_process	regulation of cell growth
B	0001819	biological_process	positive regulation of cytokine production
B	0001822	biological_process	kidney development
B	0001974	biological_process	blood vessel remodeling
B	0002016	biological_process	regulation of blood volume by renin-angiotensin
B	0002018	biological_process	renin-angiotensin regulation of aldosterone production
B	0002019	biological_process	regulation of renal output by angiotensin
B	0002034	biological_process	maintenance of blood vessel diameter homeostasis by renin-angiotensin
B	0003014	biological_process	renal system process
B	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007199	biological_process	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0007267	biological_process	cell-cell signaling
B	0008083	molecular_function	growth factor activity
B	0008217	biological_process	regulation of blood pressure
B	0010595	biological_process	positive regulation of endothelial cell migration
B	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
B	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
B	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
B	0014873	biological_process	response to muscle activity involved in regulation of muscle adaptation
B	0019229	biological_process	regulation of vasoconstriction
B	0031012	cellular_component	extracellular matrix
B	0031702	molecular_function	type 1 angiotensin receptor binding
B	0031703	molecular_function	type 2 angiotensin receptor binding
B	0034374	biological_process	low-density lipoprotein particle remodeling
B	0035813	biological_process	regulation of renal sodium excretion
B	0038060	biological_process	nitric oxide-cGMP-mediated signaling
B	0038166	biological_process	angiotensin-activated signaling pathway
B	0042127	biological_process	regulation of cell population proliferation
B	0042310	biological_process	vasoconstriction
B	0042981	biological_process	regulation of apoptotic process
B	0043407	biological_process	negative regulation of MAP kinase activity
B	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0048146	biological_process	positive regulation of fibroblast proliferation
B	0050729	biological_process	positive regulation of inflammatory response
B	0051387	biological_process	negative regulation of neurotrophin TRK receptor signaling pathway
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
B	0090190	biological_process	positive regulation of branching involved in ureteric bud morphogenesis
B	0090205	biological_process	positive regulation of cholesterol metabolic process
B	0097746	biological_process	blood vessel diameter maintenance
B	1901201	biological_process	regulation of extracellular matrix assembly
B	1901203	biological_process	positive regulation of extracellular matrix assembly
B	1902895	biological_process	positive regulation of miRNA transcription
B	1903598	biological_process	positive regulation of gap junction assembly
B	1903779	biological_process	regulation of cardiac conduction
B	1990776	biological_process	response to angiotensin
B	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
B	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway
C	0001822	biological_process	kidney development
C	0001823	biological_process	mesonephros development
C	0002003	biological_process	angiotensin maturation
C	0004175	molecular_function	endopeptidase activity
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0005102	molecular_function	signaling receptor binding
C	0005159	molecular_function	insulin-like growth factor receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0008217	biological_process	regulation of blood pressure
C	0008233	molecular_function	peptidase activity
C	0008584	biological_process	male gonad development
C	0009410	biological_process	response to xenobiotic stimulus
C	0010467	biological_process	gene expression
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0032496	biological_process	response to lipopolysaccharide
C	0035902	biological_process	response to immobilization stress
C	0043408	biological_process	regulation of MAPK cascade
C	0045177	cellular_component	apical part of cell
C	0051591	biological_process	response to cAMP
C	0070305	biological_process	response to cGMP
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0072051	biological_process	juxtaglomerular apparatus development
D	0001558	biological_process	regulation of cell growth
D	0001819	biological_process	positive regulation of cytokine production
D	0001822	biological_process	kidney development
D	0001974	biological_process	blood vessel remodeling
D	0002016	biological_process	regulation of blood volume by renin-angiotensin
D	0002018	biological_process	renin-angiotensin regulation of aldosterone production
D	0002019	biological_process	regulation of renal output by angiotensin
D	0002034	biological_process	maintenance of blood vessel diameter homeostasis by renin-angiotensin
D	0003014	biological_process	renal system process
D	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007199	biological_process	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
D	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0008083	molecular_function	growth factor activity
D	0008217	biological_process	regulation of blood pressure
D	0010595	biological_process	positive regulation of endothelial cell migration
D	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
D	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
D	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
D	0014873	biological_process	response to muscle activity involved in regulation of muscle adaptation
D	0019229	biological_process	regulation of vasoconstriction
D	0031012	cellular_component	extracellular matrix
D	0031702	molecular_function	type 1 angiotensin receptor binding
D	0031703	molecular_function	type 2 angiotensin receptor binding
D	0034374	biological_process	low-density lipoprotein particle remodeling
D	0035813	biological_process	regulation of renal sodium excretion
D	0038060	biological_process	nitric oxide-cGMP-mediated signaling
D	0038166	biological_process	angiotensin-activated signaling pathway
D	0042127	biological_process	regulation of cell population proliferation
D	0042310	biological_process	vasoconstriction
D	0042981	biological_process	regulation of apoptotic process
D	0043407	biological_process	negative regulation of MAP kinase activity
D	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0048146	biological_process	positive regulation of fibroblast proliferation
D	0050729	biological_process	positive regulation of inflammatory response
D	0051387	biological_process	negative regulation of neurotrophin TRK receptor signaling pathway
D	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
D	0090190	biological_process	positive regulation of branching involved in ureteric bud morphogenesis
D	0090205	biological_process	positive regulation of cholesterol metabolic process
D	0097746	biological_process	blood vessel diameter maintenance
D	1901201	biological_process	regulation of extracellular matrix assembly
D	1901203	biological_process	positive regulation of extracellular matrix assembly
D	1902895	biological_process	positive regulation of miRNA transcription
D	1903598	biological_process	positive regulation of gap junction assembly
D	1903779	biological_process	regulation of cardiac conduction
D	1990776	biological_process	response to angiotensin
D	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
D	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway
E	0001822	biological_process	kidney development
E	0001823	biological_process	mesonephros development
E	0002003	biological_process	angiotensin maturation
E	0004175	molecular_function	endopeptidase activity
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0005102	molecular_function	signaling receptor binding
E	0005159	molecular_function	insulin-like growth factor receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005886	cellular_component	plasma membrane
E	0006508	biological_process	proteolysis
E	0008217	biological_process	regulation of blood pressure
E	0008233	molecular_function	peptidase activity
E	0008584	biological_process	male gonad development
E	0009410	biological_process	response to xenobiotic stimulus
E	0010467	biological_process	gene expression
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0032496	biological_process	response to lipopolysaccharide
E	0035902	biological_process	response to immobilization stress
E	0043408	biological_process	regulation of MAPK cascade
E	0045177	cellular_component	apical part of cell
E	0051591	biological_process	response to cAMP
E	0070305	biological_process	response to cGMP
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0072051	biological_process	juxtaglomerular apparatus development
F	0001558	biological_process	regulation of cell growth
F	0001819	biological_process	positive regulation of cytokine production
F	0001822	biological_process	kidney development
F	0001974	biological_process	blood vessel remodeling
F	0002016	biological_process	regulation of blood volume by renin-angiotensin
F	0002018	biological_process	renin-angiotensin regulation of aldosterone production
F	0002019	biological_process	regulation of renal output by angiotensin
F	0002034	biological_process	maintenance of blood vessel diameter homeostasis by renin-angiotensin
F	0003014	biological_process	renal system process
F	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0005179	molecular_function	hormone activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007199	biological_process	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
F	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
F	0007267	biological_process	cell-cell signaling
F	0008083	molecular_function	growth factor activity
F	0008217	biological_process	regulation of blood pressure
F	0010595	biological_process	positive regulation of endothelial cell migration
F	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
F	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
F	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
F	0014873	biological_process	response to muscle activity involved in regulation of muscle adaptation
F	0019229	biological_process	regulation of vasoconstriction
F	0031012	cellular_component	extracellular matrix
F	0031702	molecular_function	type 1 angiotensin receptor binding
F	0031703	molecular_function	type 2 angiotensin receptor binding
F	0034374	biological_process	low-density lipoprotein particle remodeling
F	0035813	biological_process	regulation of renal sodium excretion
F	0038060	biological_process	nitric oxide-cGMP-mediated signaling
F	0038166	biological_process	angiotensin-activated signaling pathway
F	0042127	biological_process	regulation of cell population proliferation
F	0042310	biological_process	vasoconstriction
F	0042981	biological_process	regulation of apoptotic process
F	0043407	biological_process	negative regulation of MAP kinase activity
F	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050729	biological_process	positive regulation of inflammatory response
F	0051387	biological_process	negative regulation of neurotrophin TRK receptor signaling pathway
F	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0070062	cellular_component	extracellular exosome
F	0072562	cellular_component	blood microparticle
F	0090190	biological_process	positive regulation of branching involved in ureteric bud morphogenesis
F	0090205	biological_process	positive regulation of cholesterol metabolic process
F	0097746	biological_process	blood vessel diameter maintenance
F	1901201	biological_process	regulation of extracellular matrix assembly
F	1901203	biological_process	positive regulation of extracellular matrix assembly
F	1902895	biological_process	positive regulation of miRNA transcription
F	1903598	biological_process	positive regulation of gap junction assembly
F	1903779	biological_process	regulation of cardiac conduction
F	1990776	biological_process	response to angiotensin
F	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
F	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway
G	0001822	biological_process	kidney development
G	0001823	biological_process	mesonephros development
G	0002003	biological_process	angiotensin maturation
G	0004175	molecular_function	endopeptidase activity
G	0004190	molecular_function	aspartic-type endopeptidase activity
G	0005102	molecular_function	signaling receptor binding
G	0005159	molecular_function	insulin-like growth factor receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0008217	biological_process	regulation of blood pressure
G	0008233	molecular_function	peptidase activity
G	0008584	biological_process	male gonad development
G	0009410	biological_process	response to xenobiotic stimulus
G	0010467	biological_process	gene expression
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0032496	biological_process	response to lipopolysaccharide
G	0035902	biological_process	response to immobilization stress
G	0043408	biological_process	regulation of MAPK cascade
G	0045177	cellular_component	apical part of cell
G	0051591	biological_process	response to cAMP
G	0070305	biological_process	response to cGMP
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	0072051	biological_process	juxtaglomerular apparatus development
H	0001558	biological_process	regulation of cell growth
H	0001819	biological_process	positive regulation of cytokine production
H	0001822	biological_process	kidney development
H	0001974	biological_process	blood vessel remodeling
H	0002016	biological_process	regulation of blood volume by renin-angiotensin
H	0002018	biological_process	renin-angiotensin regulation of aldosterone production
H	0002019	biological_process	regulation of renal output by angiotensin
H	0002034	biological_process	maintenance of blood vessel diameter homeostasis by renin-angiotensin
H	0003014	biological_process	renal system process
H	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
H	0004867	molecular_function	serine-type endopeptidase inhibitor activity
H	0005179	molecular_function	hormone activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007199	biological_process	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
H	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
H	0007267	biological_process	cell-cell signaling
H	0008083	molecular_function	growth factor activity
H	0008217	biological_process	regulation of blood pressure
H	0010595	biological_process	positive regulation of endothelial cell migration
H	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
H	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
H	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
H	0014873	biological_process	response to muscle activity involved in regulation of muscle adaptation
H	0019229	biological_process	regulation of vasoconstriction
H	0031012	cellular_component	extracellular matrix
H	0031702	molecular_function	type 1 angiotensin receptor binding
H	0031703	molecular_function	type 2 angiotensin receptor binding
H	0034374	biological_process	low-density lipoprotein particle remodeling
H	0035813	biological_process	regulation of renal sodium excretion
H	0038060	biological_process	nitric oxide-cGMP-mediated signaling
H	0038166	biological_process	angiotensin-activated signaling pathway
H	0042127	biological_process	regulation of cell population proliferation
H	0042310	biological_process	vasoconstriction
H	0042981	biological_process	regulation of apoptotic process
H	0043407	biological_process	negative regulation of MAP kinase activity
H	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0048146	biological_process	positive regulation of fibroblast proliferation
H	0050729	biological_process	positive regulation of inflammatory response
H	0051387	biological_process	negative regulation of neurotrophin TRK receptor signaling pathway
H	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
H	0070062	cellular_component	extracellular exosome
H	0072562	cellular_component	blood microparticle
H	0090190	biological_process	positive regulation of branching involved in ureteric bud morphogenesis
H	0090205	biological_process	positive regulation of cholesterol metabolic process
H	0097746	biological_process	blood vessel diameter maintenance
H	1901201	biological_process	regulation of extracellular matrix assembly
H	1901203	biological_process	positive regulation of extracellular matrix assembly
H	1902895	biological_process	positive regulation of miRNA transcription
H	1903598	biological_process	positive regulation of gap junction assembly
H	1903779	biological_process	regulation of cardiac conduction
H	1990776	biological_process	response to angiotensin
H	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
H	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV

Chain	Residue	Details
A	VAL30-VAL41
A	ALA216-GLY227

---

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. VTLNRPFLFaV

Chain	Residue	Details
B	VAL421-VAL431

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PubMed","id":"20927107","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2493678","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Peptide: {"description":"Angiotensin-4","featureId":"PRO_0000420663","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3934016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3934016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---