2WZX

AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA)IN COMPLEX WITH compound M-02

Summary for 2WZX

• Entry DOI: 10.2210/pdb2wzx/pdb
• Related: 2WZZ
• Descriptor: BETA-LACTAMASE, (3R)-1-[(4S)-azepan-4-ylcarbamoyl]-3-(sulfoamino)-L-proline, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, hydrolase, antibiotic resistance
• Biological source: PSEUDOMONAS AERUGINOSA
• Cellular location: Periplasm (By similarity): P24735
• Total number of polymer chains: 1
• Total formula weight: 41109.81

Authors

Fitzgerald, P.M.D.,Sharma, N.,Lu, J. (deposition date: 2009-12-03, release date: 2010-01-12, Last modification date: 2024-10-23)

Primary citation

Blizzard, T.A.,Chen, H.,Kim, S.,Wu, J.,Young, K.,Park, Y.,Ogawa, A.,Raghoobar, S.,Painter, R.E.,Hairston, N.,Lee, S.H.,Misura, A.,Felcetto, T.,Fitzgerald, P.M.D.,Sharma, N.,Lu, J.,Ha, S.,Hickey, E.,Hermes, J.,Hammond, M.L.
Side Chain Sar of Bicyclic Beta-Lactamase Inhibitors (Blis). 1. Discovery of a Class C Bli for Combination with Imipinem.
Bioorg.Med.Chem.Lett., 20:918-, 2010

PubMed Abstract: Bridged monobactam beta-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C beta-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro and in vivo assays and was selected for preclinical development.

PubMed: 20044254
DOI: 10.1016/J.BMCL.2009.12.069

Experimental method

X-RAY DIFFRACTION (1.4 Å)