2WZD

The catalytically active fully closed conformation of human phosphoglycerate kinase K219A mutant in complex with ADP, 3PG and aluminium trifluoride

Summary for 2WZD

Entry DOI	10.2210/pdb2wzd/pdb
Related	2WZB 2WZC
Descriptor	PHOSPHOGLYCERATE KINASE 1, MAGNESIUM ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	transferase, hereditary hemolytic anemia, phosphoprotein, kinase, glycolysis, nucleotide-binding
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P00558
Total number of polymer chains	1
Total formula weight	45371.51
Authors	Bowler, M.W.,Cliff, M.J.,Marston, J.P.M.,Baxter, N.J.,Hownslow, A.M.H.,Varga, A.V.,Szabo, J.,Vas, M.,Blackburn, G.M.,Waltho, J.P. (deposition date: 2009-11-27, release date: 2010-04-14, Last modification date: 2023-12-20)
Primary citation	Cliff, M.J.,Bowler, M.W.,Szabo, J.,Marston, J.P.M.,Varga, A.V.,Hownslow, A.M.H.,Baxter, N.J.,Blackburn, G.M.,Vas, M.,Waltho, J.P. Transition State Analogue Structures of Human Phosphoglycerate Kinase Establish the Importance of Charge Balance in Catalysis. J.Am.Chem.Soc., 132:6507-, 2010 Cited by PubMed: 20397725 DOI: 10.1021/JA100974T PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation