2WYN

Structure of family 37 trehalase from Escherichia coli in complex with a casuarine-6-O-a-D-glucoside analogue

Summary for 2WYN

• Entry DOI: 10.2210/pdb2wyn/pdb
• Related: 2JF4 2JG0 2JJB
• Descriptor: PERIPLASMIC TREHALASE, (1R,2R,3R,6R,7R,7AR)-3,7-BIS(HYDROXYMETHYL)HEXAHYDRO-1H-PYRROLIZINE-1,2,6-TRIOL, alpha-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: hydrolase, glycosidase, glycoside hydrolase
• Biological source: ESCHERICHIA COLI
• Total number of polymer chains: 4
• Total formula weight: 246817.78

Authors

Gloster, T.M.,Roberts, S.M.,Davies, G.J.,Cardona, F.,Goti, A.,Parmeggiani, C.,Parenti, P.,Fusi, P.,Forcella, M.,Cipolla, L. (deposition date: 2009-11-17, release date: 2010-09-29, Last modification date: 2024-10-16)

Primary citation

Cardona, F.,Goti, A.,Parmeggiani, C.,Parenti, P.,Forcella, M.,Fusi, P.,Cipolla, L.,Roberts, S.M.,Davies, G.J.,Gloster, T.M.
Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.
Chem.Commun.(Camb.), 46:2629-2631, 2010

PubMed Abstract: Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

PubMed: 20461849
DOI: 10.1039/b926600c

Experimental method

X-RAY DIFFRACTION (2.1 Å)