2WWJ

STRUCTURE OF JMJD2A COMPLEXED WITH INHIBITOR 10A

2WWJ の概要

• エントリーDOI: 10.2210/pdb2wwj/pdb
• 関連するPDBエントリー: 2GF7 2GFA 2GP3 2GP5 2VD7
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: chromatin regulator, double-stranded beta helix, oxidoreductase, transcription, oxygenase, host-virus interaction, transcription regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82001.26

構造登録者

Rose, N.R.,Clifton, I.J.,Oppermann, U.,McDonough, M.A.,Schofield, C.J. (登録日: 2009-10-23, 公開日: 2010-03-09, 最終更新日: 2023-12-20)

• 主引用文献: Rose, N.R.,Woon, E.C.,Kingham, G.L.,King, O.N.,Mecinovic, J.,Clifton, I.J.,Ng, S.S.,Talib-Hardy, J.,Oppermann, U.,McDonough, M.A.,Schofield, C.J.; Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.; J. Med. Chem., 53:1810-1818, 2010; PubMed: 20088513; DOI: 10.1021/jm901680b

実験手法

X-RAY DIFFRACTION (2.6 Å)