2WVJ
Mutation of Thr163 to Ser in Human Thymidine Kinase Shifts the Specificity from Thymidine towards the Nucleoside Analogue Azidothymidine
Summary for 2WVJ
Entry DOI | 10.2210/pdb2wvj/pdb |
Related | 1W4R 1XBT 2WVL |
Descriptor | THYMIDINE KINASE, CYTOSOLIC, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION, ... (5 entities in total) |
Functional Keywords | zinc-binding domain, deoxyribonucleoside kinase, feedback inhibitor, nucleotide-binding, kinase, cytoplasm, transferase, atp-binding, dna synthesis, phosphoprotein, phosphorylation |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 8 |
Total formula weight | 174957.33 |
Authors | Skovgaard, T.,Uhlin, U.,Munch-Petersen, B. (deposition date: 2009-10-17, release date: 2009-10-27, Last modification date: 2023-12-20) |
Primary citation | Skovgaard, T.,Uhlin, U.,Munch-Petersen, B. Comparative Active-Site Mutation Study of Human and Caenorhabditis Elegans Thymidine Kinase 1. FEBS J., 279:1777-, 2012 Cited by PubMed: 22385435DOI: 10.1111/J.1742-4658.2012.08554.X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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