2WVJ
Mutation of Thr163 to Ser in Human Thymidine Kinase Shifts the Specificity from Thymidine towards the Nucleoside Analogue Azidothymidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | THYMIDINE KINASE, CYTOSOLIC | polymer | 193 | 21313.0 | 8 | UniProt (P04183) Pfam (PF00265) | HOMO SAPIENS (HUMAN) | THYMIDINE KINASE 1 |
| 2 | I, K, M, O, R... (A, B, C, D, E...) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 8 | Chemie (TTP) | |||
| 3 | AA, J, L, N, Q... (H, A, B, C, D...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 4 | P, W, Z (D, G, H) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | BA, CA, DA, EA, FA... (A, B, C, D, E...) | water | water | 18.0 | 1074 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 193 (UniProt: P04183)
| PDB | External Database | Details |
|---|---|---|
| Ser 163 | Thr 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 170503.8 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 4453.5 | |
| All* | Total formula weight | 174957.3 |
