2WV4
Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction
2WV4 の概要
エントリーDOI | 10.2210/pdb2wv4/pdb |
関連するPDBエントリー | 1ZBA 1ZBE 2BHG 2J92 2WV5 |
分子名称 | PICORNAIN 3C, FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN (3 entities in total) |
機能のキーワード | hydrolase peptide complex, 3c protease, hydrolase, viral protein, hydrolase-peptide complex, hydrolase/peptide |
由来する生物種 | FOOT-AND-MOUTH DISEASE VIRUS 詳細 |
細胞内の位置 | Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B-1: Virion (Potential). Protein 3B-2: Virion (Potential). Protein 3B-3: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03306 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 48385.93 |
構造登録者 | Zunszain, P.A.,Knox, S.R.,Sweeney, T.R.,Yang, J.,Roque-Rosell, N.,Belsham, G.J.,Leatherbarrow, R.J.,Curry, S. (登録日: 2009-10-13, 公開日: 2009-10-27, 最終更新日: 2023-12-20) |
主引用文献 | Zunszain, P.A.,Knox, S.R.,Sweeney, T.R.,Yang, J.,Roque-Rosell, N.,Belsham, G.J.,Leatherbarrow, R.J.,Curry, S. Insights Into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate. J.Mol.Biol., 395:375-, 2010 Cited by PubMed: 19883658DOI: 10.1016/J.JMB.2009.10.048 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
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