2WTX

Insight into the mechanism of enzymatic glycosyltransfer with retention through the synthesis and analysis of bisubstrate glycomimetics of trehalose-6-phosphate synthase

Summary for 2WTX

Entry DOI	10.2210/pdb2wtx/pdb
Related	1GZ5 1UQT 1UQU
Descriptor	ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING], 1,2-ETHANEDIOL, URIDINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	trehalose synthase, glycosyltransferase, potassium, retention, transferase, stress response
Biological source	ESCHERICHIA COLI
Total number of polymer chains	4
Total formula weight	218292.20
Authors	Errey, J.C.,Lee, S.S.,Gibson, R.P.,Martinez-Fleites, C.,Barry, C.S.,Jung, P.M.J.,OSullivan, A.,Davis, B.G.,Davies, G.J. (deposition date: 2009-09-25, release date: 2010-02-23, Last modification date: 2023-12-20)
Primary citation	Errey, J.C.,Lee, S.S.,Gibson, R.P.,Martinez Fleites, C.,Barry, C.S.,Jung, P.M.J.,O'Sullivan, A.C.,Davis, B.G.,Davies, G.J. Mechanistic Insight Into Enzymatic Glycosyl Transfer with Retention of Configuration Through Analysis of Glycomimetic Inhibitors. Angew.Chem.Int.Ed.Engl., 49:1234-, 2010 Cited by PubMed: 20077550 DOI: 10.1002/ANIE.200905096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation