2WTI

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR

2WTI の概要

• エントリーDOI: 10.2210/pdb2wti/pdb
• 関連するPDBエントリー: 2WTC 2WTD 2WTJ
• 分子名称: CHECKPOINT KINASE 2, 4-[2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ... (5 entities in total)
• 機能のキーワード: transferase, kinase, cell cycle, li-fraumeni syndrome
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37713.38

構造登録者

Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. (登録日: 2009-09-16, 公開日: 2009-12-29, 最終更新日: 2023-12-20)

• 主引用文献: Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I.; Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2; Bioorg.Med.Chem., 18:707-, 2010; PubMed: 20022510; DOI: 10.1016/J.BMC.2009.11.058

実験手法

X-RAY DIFFRACTION (2.5 Å)