2WOU

ALK5 IN COMPLEX WITH 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2-pyridyl) amino)benzenesulfonamide

2WOU の概要

• エントリーDOI: 10.2210/pdb2wou/pdb
• 関連するPDBエントリー: 1B6C 1IAS 1PY5 1RW8 1VJY 2WOT
• 分子名称: TGF-BETA RECEPTOR TYPE-1, 1,2-ETHANEDIOL, 4-({4-[(2,6-DIMETHYLPYRIDIN-3-YL)OXY]PYRIDIN-2-YL}AMINO)BENZENESULFONAMIDE, ... (4 entities in total)
• 機能のキーワード: transferase, serine/threonine-protein kinase, alk, atp-binding, kinase inhibitor, nucleotide-binding, tgf beta type i receptor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35371.69

構造登録者

Debreczeni, J.E.,Norman, R.A.,Goldberg, F.W.,Ward, R.A.,Finlay, R.,Powell, S.J.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L. (登録日: 2009-07-28, 公開日: 2009-09-22, 最終更新日: 2024-05-08)

• 主引用文献: Goldberg, F.W.,Ward, R.A.,Powell, S.J.,Debreczeni, J.E.,Norman, R.A.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L.; Rapid Generation of a High Quality Lead for Transforming Growth Factor-Beta (Tgf-Beta) Type I Receptor (Alk5).; J.Med.Chem., 52:7901-, 2009; PubMed: 19736928; DOI: 10.1021/JM900807W

実験手法

X-RAY DIFFRACTION (2.3 Å)