2WO6
Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide
Summary for 2WO6
Entry DOI | 10.2210/pdb2wo6/pdb |
Related | 2VX3 |
Descriptor | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, ARTIFICIAL CONSENSUS SEQUENCE, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide, ... (5 entities in total) |
Functional Keywords | transferase-peptide complex, transferase peptide complex, serine/threonine-protein atp-binding, phosphoprotein, nucleotide-binding, dyrk1, dyrk1a, kinase, nucleus, transferase, tyrosine-protein kinase, transferase/peptide |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus speckle: Q13627 |
Total number of polymer chains | 3 |
Total formula weight | 90820.57 |
Authors | Roos, A.K.,Soundararajan, M.,Elkins, J.M.,Fedorov, O.,Eswaran, J.,Phillips, C.,Pike, A.C.W.,Ugochukwu, E.,Muniz, J.R.C.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Wikstrom, M.,Edwards, A.,Bountra, C.,Knapp, S. (deposition date: 2009-07-22, release date: 2009-08-18, Last modification date: 2023-12-20) |
Primary citation | Soundararajan, M.,Roos, A.K.,Savitsky, P.,Filippakopoulos, P.,Kettenbach, A.N.,Olsen, J.V.,Gerber, S.A.,Eswaran, J.,Knapp, S.,Elkins, J.M. Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition. Structure, 21:986-, 2013 Cited by PubMed: 23665168DOI: 10.1016/J.STR.2013.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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