2WNS

Human Orotate phosphoribosyltransferase (OPRTase) domain of Uridine 5' -monophosphate synthase (UMPS) in complex with its substrate orotidine 5'-monophosphate (OMP)

Summary for 2WNS

• Entry DOI: 10.2210/pdb2wns/pdb
• Related: 2JGY 2V30
• Descriptor: OROTATE PHOSPHORIBOSYLTRANSFERASE, OROTIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: alternative splicing, multifunctional enzyme, lyase, transferase, polymorphism, decarboxylase, phosphoprotein, disease mutation, glycosyltransferase, pyrimidine biosynthesis
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 46002.22

Authors

Moche, M.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotyenova, T.,Kotzch, A.,Nielsen, T.K.,Nyman, T.,Persson, C.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,VanDenBerg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P. (deposition date: 2009-07-19, release date: 2009-08-11, Last modification date: 2023-12-13)

• Primary citation: Moche, M.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotyenova, T.,Kotzch, A.,Nielsen, T.K.,Nyman, T.,Persson, C.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Vandenberg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.; Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with its Substrate Orotidine 5'-Monophosphate (Omp); To be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)