2WNS

Human Orotate phosphoribosyltransferase (OPRTase) domain of Uridine 5' -monophosphate synthase (UMPS) in complex with its substrate orotidine 5'-monophosphate (OMP)

2WNS の概要

• エントリーDOI: 10.2210/pdb2wns/pdb
• 関連するPDBエントリー: 2JGY 2V30
• 分子名称: OROTATE PHOSPHORIBOSYLTRANSFERASE, OROTIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: alternative splicing, multifunctional enzyme, lyase, transferase, polymorphism, decarboxylase, phosphoprotein, disease mutation, glycosyltransferase, pyrimidine biosynthesis
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46002.22

構造登録者

Moche, M.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotyenova, T.,Kotzch, A.,Nielsen, T.K.,Nyman, T.,Persson, C.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,VanDenBerg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P. (登録日: 2009-07-19, 公開日: 2009-08-11, 最終更新日: 2023-12-13)

• 主引用文献: Moche, M.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotyenova, T.,Kotzch, A.,Nielsen, T.K.,Nyman, T.,Persson, C.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Vandenberg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.; Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with its Substrate Orotidine 5'-Monophosphate (Omp); To be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)