2WFN

Filamin A actin binding domain

Summary for 2WFN

Entry DOI	10.2210/pdb2wfn/pdb
Related	2AAV 2BP3 2BRQ 2J3S 2JF1 2W0P
Descriptor	FILAMIN-A, SULFATE ION (3 entities in total)
Functional Keywords	contractile protein, phosphoprotein, disease mutation, cytoplasm, alternative splicing, cytoskeleton, actin-binding, polymorphism, acetylation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cell cortex: P21333
Total number of polymer chains	2
Total formula weight	63175.73
Authors	Ruskamo, S.,Ylanne, J. (deposition date: 2009-04-09, release date: 2009-10-27, Last modification date: 2023-12-13)
Primary citation	Ruskamo, S.,Ylanne, J. Structure of the Human Filamin a Actin-Binding Domain Acta Crystallogr.,Sect.D, 65:1217-, 2009 Cited by PubMed Abstract: Filamin A (FLNa) is a large dimeric protein that binds to actin filaments via its actin-binding domain (ABD). The crystal structure of this domain was solved at 3.2 A resolution. The domain adopts a closed conformation typical of other ABDs, but also forms a dimer both in crystallization conditions and in solution. The structure shows the localization of the residues mutated in patients with periventricular nodular heterotopia or otopalatodigital syndrome. Structural analysis predicts that mutations in both types of disorder may affect actin binding. PubMed: 19923718 DOI: 10.1107/S0907444909037330 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation