2WAP

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with the drug-like urea inhibitor PF-3845

Summary for 2WAP

Entry DOI	10.2210/pdb2wap/pdb
Related	1MT5 2VYA
Descriptor	FATTY-ACID AMIDE HYDROLASE 1, 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	fatty acid amide hydrolase, urea inhibitor, golgi apparatus, endoplasmic reticulum, acyl- enzyme, transmembrane, phosphoprotein, faah, drug, membrane, hydrolase, inhibitor
Biological source	RATTUS NORVEGICUS (RAT)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	120519.18
Authors	Mileni, M.,Kamtekar, S.,Stevens, R.C. (deposition date: 2009-02-11, release date: 2009-05-05, Last modification date: 2023-12-13)
Primary citation	Ahn, K.,Johnson, D.S.,Mileni, M.,Beidler, D.,Long, J.Z.,Mckinney, M.K.,Weerapana, E.,Sadagopan, N.,Liimatta, M.,Smith, S.E.,Lazerwith, S.,Stiff, C.,Kamtekar, S.,Bhattacharya, K.,Zhang, Y.,Swaney, S.,Vanbecelaere, K.,Stevens, R.C.,Cravatt, B.F. Discovery and Characterization of a Highly Selective Faah Inhibitor that Reduces Inflammatory Pain. Chem.Biol., 16:411-, 2009 Cited by PubMed: 19389627 DOI: 10.1016/J.CHEMBIOL.2009.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation