2W9S

Staphylococcus aureus S1:DHFR in complex with trimethoprim

2W9S の概要

• エントリーDOI: 10.2210/pdb2w9s/pdb
• 関連するPDBエントリー: 2W9T
• 分子名称: DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: antibiotic resistance, dhfr, nadp, oxidoreductase, trimethoprim resistance, one-carbon metabolism, methotrexate resistance
• 由来する生物種: STAPHYLOCOCCUS AUREUS
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 115536.66

構造登録者

Soutter, H.H.,Miller, J.R. (登録日: 2009-01-28, 公開日: 2009-03-24, 最終更新日: 2011-07-13)

• 主引用文献: Heaslet, H.,Harris, M.,Fahnoe, K.,Sarver, R.,Putz, H.,Chang, J.,Subramanian, C.,Barreiro, G.,Miller, J.R.; Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus Aureus in Complex with the Potent Inhibitor Trimethoprim.; Proteins, 76:706-, 2009; PubMed: 19280600; DOI: 10.1002/PROT.22383

実験手法

X-RAY DIFFRACTION (1.8 Å)