2W9T

Staphylococcus aureus S1:DHFR

Summary for 2W9T

Entry DOI	10.2210/pdb2w9t/pdb
Related	2W9S
Descriptor	DIHYDROFOLATE REDUCTASE TYPE 1 (2 entities in total)
Functional Keywords	antibiotic resistance, staphylococcus aureus, dhfr, nadp, plasmid, trimethoprim, oxidoreductase, trimethoprim resistance, one-carbon metabolism, methotrexate resistance
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	2
Total formula weight	37001.98
Authors	Soutter, H.H.,Miller, J.R. (deposition date: 2009-01-28, release date: 2009-03-24, Last modification date: 2011-07-13)
Primary citation	Heaslet, H.,Harris, M.,Fahnoe, K.,Sarver, R.,Putz, H.,Chang, J.,Subramanyam, C.,Barreiro, G.,Miller, J.R. Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus Aureus in Complex with the Potent Inhibitor Trimethoprim. Proteins, 76:706-, 2009 Cited by PubMed: 19280600 DOI: 10.1002/PROT.22383 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation