2W9S

Staphylococcus aureus S1:DHFR in complex with trimethoprim

Summary for 2W9S

Entry DOI	10.2210/pdb2w9s/pdb
Related	2W9T
Descriptor	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	antibiotic resistance, dhfr, nadp, oxidoreductase, trimethoprim resistance, one-carbon metabolism, methotrexate resistance
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	6
Total formula weight	115536.66
Authors	Soutter, H.H.,Miller, J.R. (deposition date: 2009-01-28, release date: 2009-03-24, Last modification date: 2011-07-13)
Primary citation	Heaslet, H.,Harris, M.,Fahnoe, K.,Sarver, R.,Putz, H.,Chang, J.,Subramanian, C.,Barreiro, G.,Miller, J.R. Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus Aureus in Complex with the Potent Inhibitor Trimethoprim. Proteins, 76:706-, 2009 Cited by PubMed: 19280600 DOI: 10.1002/PROT.22383 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation