2W9S
Staphylococcus aureus S1:DHFR in complex with trimethoprim
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003 | polymer | 161 | 18501.0 | 6 | UniProt (P13955) Pfam (PF00186) | STAPHYLOCOCCUS AUREUS | DEHYDROFOLATE REDUCTASE |
| 2 | G, J, M, Q, R... (A, B, C, E, F) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 3 | H, K, N (A, B, C) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 3 | Chemie (NDP) | |||
| 4 | I, L, O, P, S... (A, B, C, D, E...) | TRIMETHOPRIM | non-polymer | 290.3 | 6 | Chemie (TOP) | |||
| 5 | AA, V, W, X, Y... (F, A, B, C, D...) | water | water | 18.0 | 242 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 0 - 160 (UniProt: P13955)
| PDB | External Database | Details |
|---|---|---|
| Glu 48 | Asn 49 | engineered mutation |
| Asp 130 | Asn 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 111005.9 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 4530.7 | |
| All* | Total formula weight | 115536.7 |
