2W9E
Structure of ICSM 18 (anti-Prp therapeutic antibody) Fab fragment complexed with human Prp fragment 119-231
Summary for 2W9E
Entry DOI | 10.2210/pdb2w9e/pdb |
Related | 1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 |
Descriptor | MAJOR PRION PROTEIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN, ... (5 entities in total) |
Functional Keywords | fab, prp, prion, membrane, gpi-anchor, lipoprotein, golgi apparatus, disease mutation, immune system, glycoprotein, cell membrane |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Cytoplasm: P04156 |
Total number of polymer chains | 3 |
Total formula weight | 59657.04 |
Authors | Antonyuk, S.V.,Trevitt, C.R.,Strange, R.W.,Jackson, G.S.,Sangar, D.,Batchelor, M.,Jones, S.,Georgiou, T.,Cooper, S.,Fraser, C.,Khalili-Shirazi, A.,Clarke, A.R.,Hasnain, S.S.,Collinge, J. (deposition date: 2009-01-23, release date: 2009-02-03, Last modification date: 2023-12-13) |
Primary citation | Antonyuk, S.V.,Trevitt, C.R.,Strange, R.W.,Jackson, G.S.,Sangar, D.,Batchelor, M.,Cooper, S.,Fraser, C.,Jones, S.,Georgiou, T.,Khalili-Shirazi, A.,Clarke, A.R.,Hasnain, S.S.,Collinge, J. Crystal Structure of Human Prion Protein Bound to a Therapeutic Antibody. Proc.Natl.Acad.Sci.USA, 106:2554-, 2009 Cited by PubMed: 19204296DOI: 10.1073/PNAS.0809170106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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