2W99
Crystal Structure of CDK4 in complex with a D-type cyclin
Summary for 2W99
Entry DOI | 10.2210/pdb2w99/pdb |
Related | 1LD2 2W96 |
Descriptor | G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, chromosomal rearrangement, atp-binding, transferase, polymorphism, cell division, proto-oncogene, phosphoprotein, disease mutation, nucleotide-binding, cyclin dependent kinase, kinase, cyclin, oncology, cell cycle, drug desgn |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 65534.93 |
Authors | Day, P.J.,Cleasby, A.,Tickle, I.J.,Reilly, M.O.,Coyle, J.E.,Holding, F.P.,McMenamin, R.L.,Yon, J.,Chopra, R.,Lengauer, C.,Jhoti, H. (deposition date: 2009-01-22, release date: 2009-03-10, Last modification date: 2023-12-13) |
Primary citation | Day, P.J.,Cleasby, A.,Tickle, I.J.,O'Reilly, M.,Coyle, J.E.,Holding, F.P.,Mcmenamin, R.L.,Yon, J.,Chopra, R.,Lengauer, C.,Jhoti, H. Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106:4166-, 2009 Cited by PubMed: 19237565DOI: 10.1073/PNAS.0809645106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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