2W99

Crystal Structure of CDK4 in complex with a D-type cyclin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	G1/S-SPECIFIC CYCLIN-D1	polymer	271	30990.3	1	UniProt (P24385) Pfam (PF00134) Pfam (PF02984) In PDB	HOMO SAPIENS (HUMAN)	D-TYPE CYCLIN, PRAD1 ONCOGENE
2	B	CELL DIVISION PROTEIN KINASE 4	polymer	306	34544.6	1	UniProt (P11802) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	CDK4, CYCLIN-DEPENDENT KINASE 4, PSK-J3
3		water	water		18.0	126	Chemie (HOH)

Sequence modifications

B: 1 - 44 (UniProt: P11802)

PDB	External Database	Details
Glu 43	Gly 43	engineered mutation
Glu 44	Gly 44	engineered mutation

B: 48 - 303 (UniProt: P11802)

PDB	External Database	Details
Ala 172	Thr 172	engineered mutation

B: 304 - 309 (PDB: 2W99)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65534.9
All*	Total formula weight	65534.9

*Water molecules are not included.