2W8M

Structure of D212, a nuclease from a fusselovirus.

Summary for 2W8M

Entry DOI	10.2210/pdb2w8m/pdb
Descriptor	ORF D212 (2 entities in total)
Functional Keywords	ssv1, crenarchaeal virus, hydrolase
Biological source	SULFOLOBUS VIRUS RAGGED HILLS
Total number of polymer chains	2
Total formula weight	50213.44
Authors	Menon, S.K.,Young, M.J.,Lawrence, C.M. (deposition date: 2009-01-17, release date: 2009-02-03, Last modification date: 2024-05-08)
Primary citation	Menon, S.K.,Eilers, B.J.,Young, M.J.,Lawrence, C.M. The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily. J. Virol., 84:5890-5897, 2010 Cited by PubMed Abstract: Structural studies have made significant contributions to our understanding of Sulfolobus spindle-shaped viruses (Fuselloviridae), an important model system for archaeal viruses. Continuing these efforts, we report the structure of D212 from Sulfolobus spindle-shaped virus Ragged Hills. The overall fold and conservation of active site residues place D212 in the PD-(D/E)XK nuclease superfamily. The greatest structural similarity is found to the archaeal Holliday junction cleavage enzymes, strongly suggesting a role in DNA replication, repair, or recombination. Other roles associated with nuclease activity are also considered. PubMed: 20375162 DOI: 10.1128/JVI.01663-09 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation