2W81

Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H

2W81 の概要

• エントリーDOI: 10.2210/pdb2w81/pdb
• 関連するPDBエントリー: 1FHC 1HAQ 1HFH 1KOV 2G7I 2JGW 2JGX 2UWN 2V8E 2W80
• 分子名称: COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN (3 entities in total)
• 機能のキーワード: glycoprotein, immune evasion, age-related macular degeneration, innate immunity, immune response, disease mutation, factor h, complement alternate pathway, vaccine candidate, immune system
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted: P08603
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 123615.31

構造登録者

Schneider, M.C.,Prosser, B.E.,Caesar, J.J.E.,Kugelberg, E.,Li, S.,Zhang, Q.,Quoraishi, S.,Lovett, J.E.,Deane, J.E.,Sim, R.B.,Roversi, P.,Johnson, S.,Tang, C.M.,Lea, S.M. (登録日: 2009-01-08, 公開日: 2009-03-03, 最終更新日: 2023-12-13)

• 主引用文献: Schneider, M.C.,Prosser, B.E.,Caesar, J.J.E.,Kugelberg, E.,Li, S.,Zhang, Q.,Quoraishi, S.,Lovett, J.E.,Deane, J.E.,Sim, R.B.,Roversi, P.,Johnson, S.,Tang, C.M.,Lea, S.M.; Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.; Nature, 458:890-, 2009; PubMed: 19225461; DOI: 10.1038/NATURE07769

実験手法

X-RAY DIFFRACTION (2.35 Å)