2W5Z
Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide.
2W5Z の概要
エントリーDOI | 10.2210/pdb2w5z/pdb |
関連するPDBエントリー | 2AGH 2J2S 2W5Y |
分子名称 | HISTONE-LYSINE N-METHYLTRANSFERASE HRX, HISTONE PEPTIDE, ZINC ION, ... (6 entities in total) |
機能のキーワード | transcription regulation, chromosomal rearrangement, protein lysine methyltransferase, proto-oncogene, phosphoprotein, ubl conjugation, s-adenosyl-l-methionine, mixed lineage leukaemia, polymorphism, transcription, metal-binding, zinc-finger, dna-binding, bromodomain, transferase, methyltransferase, chromatin regulator, alternative splicing, histone modification, mll1, zinc, kmt2a, nucleus, apoptosis, set domain |
由来する生物種 | HOMO SAPIENS (HUMAN) 詳細 |
細胞内の位置 | Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 23939.70 |
構造登録者 | Southall, S.M.,Wong, P.S.,Odho, Z.,Roe, S.M.,Wilson, J.R. (登録日: 2008-12-15, 公開日: 2009-02-10, 最終更新日: 2011-07-13) |
主引用文献 | Southall, S.M.,Wong, P.S.,Odho, Z.,Roe, S.M.,Wilson, J.R. Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks. Mol.Cell, 33:181-, 2009 Cited by PubMed: 19187761DOI: 10.1016/J.MOLCEL.2008.12.029 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
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