2W3O

Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide

Summary for 2W3O

• Entry DOI: 10.2210/pdb2w3o/pdb
• Related: 1CDZ 1XNA 1XNT 2BRF 2D8M
• Descriptor: BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, DNA REPAIR PROTEIN XRCC1, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: hydrolase, transferase/peptide, fha, pnkp, xrcc1, kinase, nucleus, polynucleotide kinase 3' phosphatase, dna damage, dna repair, transferase, atp-binding, multifunctional enzyme, polymorphism, phosphoprotein, phospho- peptide, nucleotide-binding, base excision repair, transferase-peptide complex
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus: Q96T60 P18887
• Total number of polymer chains: 4
• Total formula weight: 26507.24

Authors

Oliver, A.W.,Ali, A.A.E.,Pearl, L.H. (deposition date: 2008-11-13, release date: 2009-02-03, Last modification date: 2023-12-13)

• Primary citation: Ali, A.A.E.,Jukes, R.M.,Pearl, L.H.,Oliver, A.W.; Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.; Nucleic Acids Res., 37:1701-, 2009; PubMed: 19155274; DOI: 10.1093/NAR/GKN1086

Experimental method

X-RAY DIFFRACTION (1.85 Å)