2W2O

PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR

2W2O の概要

• エントリーDOI: 10.2210/pdb2w2o/pdb
• 関連するPDBエントリー: 1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2W2M 2W2N 2W2P 2W2Q
• 分子名称: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase-receptor complex, pcsk9, ldlr, proprotein convertase, low-density lipoprotein receptor, egf, cardiovascular disease, familial hypercholesterolemia, lipid metabolism, serine protease, hydrolase, lipid transport, steroid metabolism, receptor, hydrolase/receptor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted: Q8NBP7; Cell membrane; Single-pass type I membrane protein: Q8NBP7
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 57971.45

構造登録者

Bottomley, M.J.,Cirillo, A.,Orsatti, L.,Ruggeri, L.,Fisher, T.S.,Santoro, J.C.,Cummings, R.T.,Cubbon, R.M.,Lo Surdo, P.,Calzetta, A.,Noto, A.,Baysarowich, J.,Mattu, M.,Talamo, F.,De Francesco, R.,Sparrow, C.P.,Sitlani, A.,Carfi, A. (登録日: 2008-11-03, 公開日: 2008-11-18, 最終更新日: 2023-12-13)

• 主引用文献: Bottomley, M.J.,Cirillo, A.,Orsatti, L.,Ruggeri, L.,Fisher, T.S.,Santoro, J.C.,Cummings, R.T.,Cubbon, R.M.,Lo Surdo, P.,Calzetta, A.,Noto, A.,Baysarowich, J.,Mattu, M.,Talamo, F.,De Francesco, R.,Sparrow, C.P.,Sitlani, A.,Carfi, A.; Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.; J.Biol.Chem., 284:1313-, 2009; PubMed: 19001363; DOI: 10.1074/JBC.M808363200

実験手法

X-RAY DIFFRACTION (2.62 Å)