2W2O
PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | polymer | 312 | 33156.3 | 1 | UniProt (Q8NBP7) Pfam (PF00082) In PDB | HOMO SAPIENS (HUMAN) | PCSK9, PROPROTEIN CONVERTASE PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1 |
2 | E | LOW-DENSITY LIPOPROTEIN RECEPTOR | polymer | 107 | 12095.5 | 1 | UniProt (P01130) In PDB | HOMO SAPIENS (HUMAN) | LDL RECEPTOR |
3 | P | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | polymer | 114 | 12679.6 | 1 | UniProt (Q8NBP7) Pfam (PF05922) In PDB | HOMO SAPIENS (HUMAN) | PCSK9, PROPROTEIN CONVERTASE PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1 |
4 | E | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
5 | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
P: 39 - 52 (PDB: 2W2O)
P: 53 - 152 (UniProt: Q8NBP7)
A: 153 - 451 (UniProt: Q8NBP7)
A: 452 - 464 (PDB: 2W2O)
E: 266 - 292 (PDB: 2W2O)
E: 293 - 372 (UniProt: P01130)
P: 53 - 152 (UniProt: Q8NBP7)
A: 153 - 451 (UniProt: Q8NBP7)
PDB | External Database | Details |
---|---|---|
Tyr 374 | Asp 374 | engineered mutation |
E: 266 - 292 (PDB: 2W2O)
E: 293 - 372 (UniProt: P01130)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 57931.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 40.1 | |
All* | Total formula weight | 57971.4 |