2W22

Activation Mechanism of Bacterial Thermoalkalophilic Lipases

Summary for 2W22

Entry DOI	10.2210/pdb2w22/pdb
Descriptor	TRIACYLGLYCEROL LIPASE, CALCIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywords	thermoalkalophilic lipases, hydrolase, open conformation, activation mechanism
Biological source	GEOBACILLUS THERMOCATENULATUS
Total number of polymer chains	1
Total formula weight	45034.00
Authors	Carrasco-Lopez, C.,Godoy, C.,De Las Rivas, B.,Fernandez-Lorente, G.,Palomo, J.M.,Guisan, J.M.,Fernandez-Lafuente, R.,Hermoso, J.A. (deposition date: 2008-10-23, release date: 2008-12-16, Last modification date: 2023-12-13)
Primary citation	Carrasco-Lopez, C.,Godoy, C.,de Las Rivas, B.,Fernandez-Lorente, G.,Palomo, J.M.,Guisan, J.M.,Fernandez-Lafuente, R.,Martinez-Ripoll, M.,Hermoso, J.A. Activation of bacterial thermoalkalophilic lipases is spurred by dramatic structural rearrangements. J. Biol. Chem., 284:4365-4372, 2009 Cited by PubMed: 19056729 DOI: 10.1074/jbc.M808268200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation