2W0S
Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate
Summary for 2W0S
| Entry DOI | 10.2210/pdb2w0s/pdb |
| Related | 2V54 |
| Descriptor | THYMIDYLATE KINASE, MAGNESIUM ION, (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | nucleotide biosynthesis, atp-binding, nucleotide-binding, kinase, poxvirus, tmp kinase, transferase |
| Biological source | VACCINIA VIRUS COPENHAGEN |
| Total number of polymer chains | 2 |
| Total formula weight | 48015.85 |
| Authors | Caillat, C.,Topalis, D.,Agrofoglio, L.A.,Pochet, S.,Balzarini, J.,Deville-Bonne, D.,Meyer, P. (deposition date: 2008-10-08, release date: 2008-10-21, Last modification date: 2023-12-13) |
| Primary citation | Caillat, C.,Topalis, D.,Agrofoglio, L.A.,Pochet, S.,Balzarini, J.,Deville-Bonne, D.,Meyer, P. Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy Proc.Natl.Acad.Sci.USA, 105:16900-, 2008 Cited by PubMed: 18971333DOI: 10.1073/PNAS.0804525105 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.918 Å) |
Structure validation
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