2W0S
Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
A | 0004798 | molecular_function | thymidylate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006227 | biological_process | dUDP biosynthetic process |
A | 0006233 | biological_process | dTDP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
B | 0004798 | molecular_function | thymidylate kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006227 | biological_process | dUDP biosynthetic process |
B | 0006233 | biological_process | dTDP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 1205 |
Chain | Residue |
B | THR18 |
B | ASN37 |
B | ASP92 |
B | BVP1207 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 1205 |
Chain | Residue |
A | THR18 |
A | ASN37 |
A | ASP92 |
A | BVP1207 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 1206 |
Chain | Residue |
A | GLU142 |
A | GLU145 |
A | BVP1207 |
A | ASP13 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 1206 |
Chain | Residue |
B | ASP13 |
B | GLU142 |
B | GLU145 |
B | BVP1207 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE BVP A 1207 |
Chain | Residue |
A | ASP13 |
A | PHE38 |
A | ARG41 |
A | VAL64 |
A | ASN65 |
A | PHE68 |
A | ARG72 |
A | ARG93 |
A | GLY98 |
A | TYR101 |
A | LYS105 |
A | TYR144 |
A | MG1205 |
A | MG1206 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE BVP B 1207 |
Chain | Residue |
B | ASP13 |
B | PHE38 |
B | ARG41 |
B | ASN65 |
B | PHE68 |
B | ARG72 |
B | ARG93 |
B | GLY98 |
B | TYR101 |
B | ALA102 |
B | LYS105 |
B | TYR144 |
B | MG1205 |
B | MG1206 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1208 |
Chain | Residue |
A | LYS14 |
A | SER15 |
A | GLY16 |
A | LYS17 |
A | THR18 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 1208 |
Chain | Residue |
B | LYS14 |
B | SER15 |
B | GLY16 |
B | LYS17 |
B | THR18 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE BVP B 1209 |
Chain | Residue |
A | ASN60 |
A | HIS62 |
A | ILE63 |
B | TRP73 |
Functional Information from PROSITE/UniProt
site_id | PS01331 |
Number of Residues | 13 |
Details | THYMIDYLATE_KINASE Thymidylate kinase signature. IVDRYafSGvAYA |
Chain | Residue | Details |
A | ILE90-ALA102 |