2W0D

Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.

2W0D の概要

• エントリーDOI: 10.2210/pdb2w0d/pdb
• 関連するPDBエントリー: 1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J
• 分子名称: MACROPHAGE METALLOELASTASE, ZINC ION, CALCIUM ION, ... (8 entities in total)
• 機能のキーワード: glycoprotein, metal-binding, metalloprotease, secreted, hydrolase, hydroxamate, extracellular matrix, copd, mmp-12, zymogen
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 76337.88

構造登録者

Isaksson, J.,Nystrom, S.,Derbyshire, D.J.,Wallberg, H.,Agback, T.,Kovacs, H.,Bertini, I.,Felli, I.C. (登録日: 2008-08-13, 公開日: 2009-03-03, 最終更新日: 2024-05-01)

• 主引用文献: Isaksson, J.,Nystrom, S.,Derbyshire, D.J.,Wallberg, H.,Agback, T.,Kovacs, H.,Bertini, I.,Felli, I.C.; Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? a Case Study of Metalloproteinases.; J.Med.Chem., 52:1712-, 2009; PubMed: 19239231; DOI: 10.1021/JM801388Q

実験手法

X-RAY DIFFRACTION (2 Å)