2VXY

The structure of FTsZ from Bacillus subtilis at 1.7A resolution

Summary for 2VXY

• Entry DOI: 10.2210/pdb2vxy/pdb
• Related: 2VAM
• Descriptor: CELL DIVISION PROTEIN FTSZ, CITRIC ACID, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: gtp-binding, cell division, nucleotide-binding, ftsz, septation, cytoplasm, b.subtilis, cell cycle, cell division protein
• Biological source: BACILLUS SUBTILIS
• Cellular location: Cytoplasm (By similarity): P17865
• Total number of polymer chains: 1
• Total formula weight: 40626.88

Authors

Barynin, V.V.,Baker, P.J.,Rice, D.W.,Sedelnikova, S.E.,Haydon, D.J.,Stokes, N.R.,Ure, R.,Galbraith, G.,Bennett, J.M.,Brown, D.R.,Heal, J.R.,Sheridan, J.M.,Aiwale, S.T.,Chauhan, P.K.,Srivastava, A.,Taneja, A.,Collins, I.,Errington, J.,Czaplewski, L.G. (deposition date: 2008-07-15, release date: 2008-09-30, Last modification date: 2023-12-13)

Primary citation

Haydon, D.J.,Stokes, N.R.,Ure, R.,Galbraith, G.,Bennett, J.M.,Brown, D.R.,Baker, P.J.,Barynin, V.V.,Rice, D.W.,Sedelnikova, S.E.,Heal, J.R.,Sheridan, J.M.,Aiwale, S.T.,Chauhan, P.K.,Srivastava, A.,Taneja, A.,Collins, I.,Errington, J.,Czaplewski, L.G.
An Inhibitor of Ftsz with Potent and Selective Anti-Staphylococcal Activity.
Science, 321:1673-, 2008

PubMed Abstract: FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian beta-tubulin that polymerizes and assembles into a ring to initiate cell division. We have created a class of small synthetic antibacterials, exemplified by PC190723, which inhibits FtsZ and prevents cell division. PC190723 has potent and selective in vitro bactericidal activity against staphylococci, including methicillin- and multi-drug-resistant Staphylococcus aureus. The putative inhibitor-binding site of PC190723 was mapped to a region of FtsZ that is analogous to the Taxol-binding site of tubulin. PC190723 was efficacious in an in vivo model of infection, curing mice infected with a lethal dose of S. aureus. The data validate FtsZ as a target for antibacterial intervention and identify PC190723 as suitable for optimization into a new anti-staphylococcal therapy.

PubMed: 18801997
DOI: 10.1126/SCIENCE.1159961

Experimental method

X-RAY DIFFRACTION (1.7 Å)