2VX3
Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A
Summary for 2VX3
Entry DOI | 10.2210/pdb2vx3/pdb |
Related | 2WO6 |
Descriptor | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | serine/threonine-protein kinase, minibrain homolog, nucleotide-binding, transferase, phosphoprotein, tyrosine-protein kinase, casp8, kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus speckle: Q13627 |
Total number of polymer chains | 4 |
Total formula weight | 183315.20 |
Authors | Roos, A.K.,Soundararajan, M.,Pike, A.C.W.,Federov, O.,King, O.,Burgess-Brown, N.,Philips, C.,Filippakopoulos, P.,Arrowsmith, C.H.,Wikstrom, M.,Edwards, A.,von Delft, F.,Bountra, C.,Knapp, S. (deposition date: 2008-06-30, release date: 2008-09-16, Last modification date: 2024-10-09) |
Primary citation | Soundararajan, M.,Roos, A.K.,Savitsky, P.,Filippakopoulos, P.,Kettenbach, A.N.,Olsen, J.V.,Gerber, S.A.,Eswaran, J.,Knapp, S.,Elkins, J.M. Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition. Structure, 21:986-, 2013 Cited by PubMed: 23665168DOI: 10.1016/J.STR.2013.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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