2VX3
Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A | polymer | 382 | 44553.2 | 4 | UniProt (Q13627) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | PROTEIN KINASE MINIBRAIN HOMOLOG, MNBH, HMNB, HP86, DUAL SPECIFICITY YAK1-RELATED KINASE |
2 | D, A, B, C | N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide | non-polymer | 447.9 | 4 | Chemie (D15) | |||
3 | D, A, B, C | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
4 | D, A, B, C | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 8 | Chemie (P6G) | |||
5 | D, A, B, C | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
6 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 127 - 485 (UniProt: Q13627)
PDB | External Database | Details |
---|---|---|
Met 104 | - | expression tag |
His 105 | - | expression tag |
His 106 | - | expression tag |
His 107 | - | expression tag |
His 108 | - | expression tag |
His 109 | - | expression tag |
His 110 | - | expression tag |
Ser 111 | - | expression tag |
Ser 112 | - | expression tag |
Gly 113 | - | expression tag |
Val 114 | - | expression tag |
Asp 115 | - | expression tag |
Leu 116 | - | expression tag |
Gly 117 | - | expression tag |
Thr 118 | - | expression tag |
Glu 119 | - | expression tag |
Asn 120 | - | expression tag |
Leu 121 | - | expression tag |
Tyr 122 | - | expression tag |
Phe 123 | - | expression tag |
Gln 124 | - | expression tag |
Ser 125 | - | expression tag |
Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 178212.8 | |
Non-Polymers* | Number of molecules | 28 |
Total formula weight | 5102.4 | |
All* | Total formula weight | 183315.2 |