2VVT

Glutamate Racemase (MurI) from E. faecalis in complex with a 9-Benzyl Purine inhibitor

Summary for 2VVT

• Entry DOI: 10.2210/pdb2vvt/pdb
• Related: 2JFO 2JFP
• Descriptor: GLUTAMATE RACEMASE, 2-butoxy-9-(2,6-difluorobenzyl)-N-(2-morpholin-4-ylethyl)-9H-purin-6-amine, D-GLUTAMIC ACID, ... (4 entities in total)
• Functional Keywords: isomerase, glutamate racemase, peptidoglycan synthesis, cell wall biogenesis/degradation, cell shape, benzyl purine, muri inhibitor
• Biological source: ENTEROCOCCUS FAECALIS
• Total number of polymer chains: 2
• Total formula weight: 63683.73

Authors

Geng, B.,Breault, G.,Comita-Prevoir, J.,Petrichko, R.,Eyermann, C.,Lundqvist, T.,Doig, P.,Gorseth, E.,Noonan, B. (deposition date: 2008-06-11, release date: 2008-06-24, Last modification date: 2023-12-13)

• Primary citation: Geng, B.,Breault, G.,Comita-Prevoir, J.,Petrichko, R.,Eyermann, C.,Lundqvist, T.,Doig, P.,Gorseth, E.,Noonan, B.; Exploring 9-Benzyl Purines as Inhibitors of Glutamate Racemase (Muri) in Gram-Positive Bacteria.; Bioorg.Med.Chem.Lett., 18:4368-, 2008; PubMed: 18614367; DOI: 10.1016/J.BMCL.2008.06.068

Experimental method

X-RAY DIFFRACTION (1.65 Å)