2VUW

Structure of human haspin kinase domain

2VUW の概要

• エントリーDOI: 10.2210/pdb2vuw/pdb
• 分子名称: SERINE/THREONINE-PROTEIN KINASE HASPIN, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (7 entities in total)
• 機能のキーワード: cell cycle, transferase, casp8, nucleotide binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q8TF76
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39389.05

構造登録者

Eswaran, J.,Murray, J.W.,Filippakopoulos, P.,Soundararajan, M.,Pike, A.C.W.,von Delft, F.,Picaud, S.,Keates, T.,King, O.,Wickstroem, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Fedorov, O.,Burgess-Brown, N.,Bray, J.,Knapp, S. (登録日: 2008-05-30, 公開日: 2008-09-16, 最終更新日: 2024-05-01)

• 主引用文献: Eswaran, J.,Patnaik, D.,Filippakopoulos, P.,Wang, F.,Stein, R.L.,Murray, J.W.,Higgins, J.M.G.,Knapp, S.; Structure and Functional Characterization of the Atypical Human Kinase Haspin.; Proc.Natl.Acad.Sci.USA, 106:20198-, 2009; PubMed: 19918057; DOI: 10.1073/PNAS.0901989106

実験手法

X-RAY DIFFRACTION (1.8 Å)